Making science work

Description

Drug development using Hot Melt Extrusion in the pharmaceutical industry

■■ Hands-on workshop on
□□ different extruders and downstream equipment
□□ workshops on 3D printing
□□ workshops on implants

Target groups

The HME hands-on workshop provides scientific and technical staff from
pharmaceutical development, clinical trial supplies and process or technology
transfer a good introduction to the establishment and application of this
new technology. For colleagues, without any prior knowledge, this hands-on
workshop provides a comprehensive introduction to the technology, while
for colleagues who already have experience with HME, the workshop offers
the opportunity to deepen their knowledge in relation to specific procedures
and methods. For employees from the production department, the
workshop offers the opportunity to acquire the essential knowledge for the
establishment of this new technology.

Objective

Hot Melt Extrusion (HME), which is a manufacturing
technique, successfully used by the plastic and food industry
since decades, gains increasing relevance for the development
and production of pharmaceuticals. Due to its advantages
for formulation and the continuous and easily controllable
process, this technology offers many advantages to realize a
modern production of pharmaceuticals.
Next to the learning about understanding and using of
Hot Melt Extrusion, this hands-on workshop will also offer
support for implementations in the context of development
projects of new pharmaceuticals – from early stage until
scale-up, transfer and production for the market. The focus is
not only on technology, process parameters, formulation and
development concepts, but also on practical implementation.
In the context of a hands-on workshop, participants will learn
how to use the technology and the machine and they will
follow 4 workshop stations; all theoretically learned topics
can be transferred into praxis. During these labs, extensive
knowledge of successful screening for the appropriate
process and formulation concepts, for the analysis of critical
quality factors, for the determination and definition of
relevant process parameters, will be communicated, as well
as scale-up concepts.
Delegates will highly benefit from the panel discussions as
well as from the discussions in their workshop groups. This
set-up will guarantee an interactive and interdisciplinary
exchange between delegates and speakers. This hands-on
workshop will happen in cooperation with Thermo Fisher
Scientific and all sessions and workshops will take place in
laboratories run by Thermo Fisher Scientific in Karlsruhe,
Germany. All workshop speakers are well-known experts
from industry and academia, and all are acknowledged
experts on HME. They will communicate the technology
and its utilization, and also demonstrate advantages and
disadvantages of different devices, methods and processes.
Workshops will happen in small groups of 5; therefore, we
need to limit the overall participant number. To make sure
you will get the best out of this hands-on workshop, we
cannot accept more than 25 participants.