Making science work

Target groups

This course is designed for all scientists, project and technical managers working in the field of oral delivery of non-Rule of 5 compounds. The course would also be of interest to those working in closely related fields such as Drug Discovery, Toxicology and Regulatory and those who wish to increase their knowledge of this highly inter-disciplinary field.

Objective

Many of today’s therapeutic candidates have physiochemical properties which fall outside the limits described by Lipinski for high oral bioavailability. These non-Rule of 5 compounds which include peptides, PROTACs, molecular glues and nucleic acids suffer from poor membrane permeability, poor water solubility or both. This workshop focuses on the latest research to understand the challenges of delivering BCS Class 3 and Class 4 compounds and the approaches and technologies being developed and used to facilitate oral delivery of such drug candidates via the GI tract.