APV TabletXpert Multi-Layer Tableting

Objective

Tablets are the most frequently used dosage form because of their ease of manufacturing and appealing properties to the patients. With increasing complexity of dissolution profiles or multiple drugs in one dosage form, more complex types of tablets become necessary. One of such complex
types of tablets are multi-layer tablets, which consist of multiple different formulations, that are compacted to one dosage form in layers. Additional challenges to those faced already in the manufacturing of simple tablets are the clean production of well-separated layers and their adhesion
at the interface between the layers in multi-layer tablets. Accordingly, specialised tablet presses, deeper formulation and process knowledge are necessary in the development of multi-layer tablets.

The course provides the theoretical foundation as well as practical experience of the multi-layer tableting process. It includes knowledge on formulation aspects, specific machine configurations and parametrisations, and specifically their interplay in forming intact products. It covers the basic formulation characterisation with specific focus on multi-layer compatibility, multi-layer tablet control
methods, formulation and process development at small scale (compaction simulator), scale transfer to production presses and trouble shooting in industrial scale processes.

At the end of the course, the participants will have acquired fundamental knowledge on the development and will be able to independently recognize and evaluate the criteria relevant to multi-layer tablet production.