APV master class on Hot Melt Extrusion (HME)

Objective

Hot Melt Extrusion (HME), which is a manufacturing technique, successfully used by the plastic and food industry since decades, gains increasing relevance for the development and production of pharmaceuticals. Due to its advantages for formulation and the continuous and easily controllable
process, this technology offers many advantages to realize a modern production of pharmaceuticals.
Next to the learning about understanding and using of Hot Melt Extrusion, this hands-on workshop will also offer support for implementations in the context of development projects of new pharmaceuticals – from early stage until scale-up, transfer and production for the market. The focus is not only on technology, process parameters, formulation and development concepts, but also on practical implementation.
In the context of a hands-on workshop, participants will learn how to use the technology and the machine and they will follow 4 workshop stations; all theoretically learned topics can be transferred into praxis. During these labs, extensive knowledge of successful screening for the appropriate process and formulation concepts, for the analysis of critical quality factors, for the determination and definition of
relevant process parameters, will be communicated, as well as scale-up concepts.
Delegates will highly benefit from the panel discussions as well as from the discussions in their workshop groups. This set-up will guarantee an interactive and interdisciplinary exchange between delegates and speakers. This hands-on workshop will happen in cooperation with Thermo Fisher Scientific and all sessions and workshops will take place in laboratories run by Thermo Fisher Scientific in Karlsruhe,
Germany. All workshop speakers are well-known experts from industry and academia, and all are acknowledged experts on HME. They will communicate the technology and its utilization, and also demonstrate advantages and disadvantages of different devices, methods and processes.
Workshops will happen in small groups of 5; therefore, we need to limit the overall participant number. To make sure you will get the best out of this hands-on workshop, we cannot accept more than 25 participants.